Catawba Hospital is located approximately eight miles from Interstate 81. If you are traveling South on I-81, take Exit 141 and turn left onto Route 419 West. If you are traveling North on I-81, take Exit 141 and turn right onto Route 419 West.
- Go 1/3 of a mile on Route 419 West.
- Turn right onto Route 311 North (at stop light).
- Stay on Route 311 North for about 7 miles across Catawba Mountain.
- Turn right onto Route 779 and follow it for about 3/4 of a mile.
- Finally turn left onto Route 320. The Main Hospital Sign is visible once you enter Route 320.